Scientists reverse ageing in mammals and predict human trials within 10 years - Politics Forum.org | PoFo

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#14750217

An end to grey hair and crows-feet could be just 10 years away after scientists showed it is possible to reverse ageing in animals.

Using a new technique which takes adult cells back to their embryonic form, US researchers at the Salk Institute in California, showed it was possible to reverse ageing in mice, allowing the animals to not only look younger, but live for 30 per cent longer.

The technique involves stimulating four genes which are particularly active during development in the womb. It was also found to work to turn the clock back on human skin cells in the lab, making them look and behave younger.

Scientists hope to eventually create a drug which can mimic the effect of the found genes which could be taken to slow down, and even reverse the ageing process. They say it will take around 10 years to get to human trials.

"Our study shows that ageing may not have to proceed in one single direction," said Dr Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory. “With careful modulation, aging might be reversed.

"Obviously, mice are not humans and we know it will be much more complex to rejuvenate a person. But this study shows that ageing is a very dynamic and plastic process, and therefore will be more amenable to therapeutic interventions than what we previously thought."


But it was always feared that allowing that to happen could damage organs made from the cells, and even trigger cancer.

However, it was discovered that stimulating the genes intermittently reversed ageing, without causing any damaging side effects.

In mice with a premature ageing disease, the treatment countered signs of ageing and increased their lifespan by 30 per cent. If it worked similarly in humans it could allow people to live until more than 100 years old. In healthy mice it also helped damaged organs to heal faster.


http://www.telegraph.co.uk/science/2016 ... ls-within/

I'll wait for the cheap no-brand knock offs.

Take care guys, and you may live a guaranteed 100+ while retaining your youth.
#14750228
In mice with a premature ageing disease, the treatment countered signs of ageing and increased their lifespan by 30 per cent. If it worked similarly in humans it could allow people to live until more than 100 years old. In healthy mice it also helped damaged organs to heal faster.


Just to be obstinate;
Why would healthy mice have damaged organs?
Why specify the treatment worked with mice with premature ageing disease?
Did it or did it not work with healthy mice? That seems to be unclear.
#14750319
I followed some of the article's links back to the original sources, and it appears a variety of different treatment modalities are being lumped in together.

The most advanced technique (targeted gene deletion) is not likely to be available in the near future. Some of the other techniques are available to those with an adventurous spirit.

Calorie restriction (CR) is the most studied method of life extension in animals. A few hearty individuals have been adopting this lifestyle, but it requires a really intimidating level of personal discipline. There are various forms of intermittent fasting (IF) that have been studied - the idea is to get most of the benefits of CR with just a fraction of the sacrifice. The most promising is FMD (fast mimicking diet); it is a patented protocol, but enough info is available online if you want to try it yourself.

There are also some CR mimetic compounds that are commercially available as supplements. There is less available evidence for their efficacy, but there is the possibility that they might have some benefit. Pterostilbene, NR (nicotinamide riboside), quercetin, PQQ (pyrroloquinoline quinone), fisetin, and the old standby resveratrol have been demonstrated to activate some of the same metabolic pathways as CR, in mice models. These are deemed generally safe, so if you have the cash, why not?

The most effective (and cheapest) strategy to extend your healthspan is to follow a primarily plant based diet emphasizing long-chain fermentable fiber, combined with some form of intermittent fasting. If you want to go full vegan, you'll need to supplement B12 and omega 3, at a minimum. This may buy enough years for real life extension modalities to be perfected.
Last edited by quetzalcoatl on 16 Dec 2016 03:24, edited 1 time in total.
#14750347
Caloric restriction really isn't something I'm interested in. I like to eat normal amounts of food. I like to be physically mobile and covered in muscle. Caloric restriction diets mimic a concentration camp lifestyle. Nein danke.

The most effective (and cheapest) strategy to extend your healthspan is to follow a primarily plant based diet emphasizing long-chain fermentable fiber, combined with some form of intermittent fasting. If you want to go full vegan, you'll need to supplement B12 and omega 3, at a minimum. This may buy enough years for real life extension modalities to be perfected.


Alternatively eat what you like and get into a 3-day/week mixed endurance/anaerobic fitness regime.

https://www.ncbi.nlm.nih.gov/pubmed/9177584


Power athletes lived 1.6 years longer
Team athletes lived 4 years longer
Endurance athletes lived 5.7 years longer


The study showed that compared to the non-athletes, the elite athletes had a much lower chance of dying at a given age, but the percentage of how much lower depended on VO2 max.

Endurance athletes had a 43% lower risk
Team athletes had 33% lower risk
Power athletes had a 10% lower risk

The study concluded that the harder your body has to work to get oxygen, the less chance you have of dying.
#14750585
Caloric restriction weakens your capacity to deal with disease or life threatening injuries*. If you're slightly overweight, you'll have a higher chance of survival than being stick-and-bone. Also, any life extending treatments will be unaffordable for most humans. In a globalized economy these drugs will only be available to the 'creme de la creme' (read: the rich).

With overpopulation already being an issue, in addition to global warming, top soil exhaustion, phosphate shortages, antibiotic resistance, deforestation, etc. This treatment won't be available for the average person. Perhaps the petro-Arabs might be able to afford it in order to extend their utterly useless existence on this planet.
Last edited by The Sabbaticus on 17 Dec 2016 08:58, edited 1 time in total.
#14750880
Igor Antunov wrote:Caloric restriction really isn't something I'm interested in. I like to eat normal amounts of food. I like to be physically mobile and covered in muscle. Caloric restriction diets mimic a concentration camp lifestyle. Nein danke.



Alternatively eat what you like and get into a 3-day/week mixed endurance/anaerobic fitness regime.

https://www.ncbi.nlm.nih.gov/pubmed/9177584


Persons of a certain phenotype are predisposed to be endurance athletes. Their phenotype may prove to be as significant as their lifestyle in their increased longevity. You can run as far as you like, but you still won't be a Kenyan. If you are genetically predisposed to atherosclerosis, what gets you the best bang for your buck? Being skinny (not muscular).

The typical gym rat pushing weights and downing boatloads of chicken breasts and whey protein is setting himself up to die of cardiovascular disease before he ever gets that gold watch.

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