Lancet retract bogus study about Hydroxychloroquine being dangerous - Politics Forum.org | PoFo

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#15097956
Covid-19: Lancet retracts paper that halted hydroxychloroquine trials
4 Jun 2020

The Lancet paper that halted global trials of hydroxychloroquine for Covid-19 because of fears of increased deaths has been retracted after a Guardian investigation found inconsistencies in the data.

The lead author, Prof Mandeep Mehra, from the Brigham and Women’s hospital in Boston, Massachusetts decided to ask the Lancet for the retraction because he could no longer vouch for the data’s accuracy.

The journal’s editor, Richard Horton, said he was appalled by developments. “This is a shocking example of research misconduct in the middle of a global health emergency,” he told the Guardian.

A Guardian investigation had revealed errors in the data that was provided for the research by US company Surgisphere. These were later explained by the company as some patients being wrongly allocated to Australia instead of Asia. But more anomalies were then picked up. A further Guardian investigation found that there were serious questions to be asked about the company itself.

In a statement on Thursday, Mehra said: “Our independent peer reviewers informed us that Surgisphere would not transfer the full dataset, client contracts, and the full ISO audit report to their servers for analysis as such transfer would violate client agreements and confidentiality requirements. As such, our reviewers were not able to conduct an independent and private peer review and therefore notified us of their withdrawal from the peer-review process.”

The Lancet study had a dramatic impact on attempts to find out whether the antimalarial drug hydroxychloroquine, and its older version, chloroquine, could help treat patients with Covid-19. The US president, Donald Trump was among those who backed the drug before any high-quality trial evidence had been published.

The World Health Organization and several countries suspended randomised controlled trials that were set up to find an answer. Those trials have now been restarted. Many scientists were angry that they had been stopped on the basis of a trial that was observational and not a “gold standard” RCT.

Mehra had commissioned an independent audit of the data after scientists questioned it.

Shortly after the Lancet retracted its study, the New England Journal of Medicine retracted a paper based on the Surgisphere database, also co-authored by Mehra and Desai. The study purported to include data from Covid-19 patients from 169 hospitals in 11 countries in Asia, Europe and North America.

In a statement, published by the journal, the authors said: “Because all the authors were not granted access to the raw data and the raw data could not be made available to a third-party auditor, we are unable to validate the primary data sources underlying our article, ‘Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19’. We therefore request that the article be retracted.

“We apologise to the editors and to readers of the Journal for the difficulties that this has caused.”

https://www.theguardian.com/world/2020/ ... ine-trials

The Lancet pulls study flagging hydroxychloroquine risks
05/06/2020

The Lancet on Thursday retracted a study that raised safety fears over the use of a drug favored by President Donald Trump to treat COVID-19, after the paper's authors said they could no longer vouch for its underlying data.

It was soon followed by the withdrawal of another coronavirus paper in the New England Journal of Medicine (NEJM) that was not linked to hydroxychloroquine but relied upon the same healthcare company's patient database.

The unfolding research scandal threatens to undermine confidence in two of the world's top medical journals in the midst of a pandemic.

But it is the retraction of The Lancet study that may supercharge what has become a highly politicized debate about hydroxychloroquine, an old malaria and rheumatoid arthritis drug now backed by many US conservatives against the SARS-CoV-2 virus.

This finding led the World Health Organization to temporarily suspend clinical trials into the medicines, though the paper soon triggered widespread concern among scientists over a lack of information about the countries and hospitals that contributed data.

But Surgisphere, a little-known healthcare analytics firm based in Chicago that provided the data, refused to cooperate.

"Due to this unfortunate development, the authors request that the paper be retracted," the three said.

"We deeply apologize to you, the editors, and the journal readership for any embarrassment or inconvenience that this may have caused."

The Lancet, a British journal, offered its own statement, saying, "There are many outstanding questions about Surgisphere and the data that were allegedly included in this study."

Researchers began to closely scrutinize The Lancet paper shortly after its publication, highlighting numerous red flags ranging from the huge number of patients to the unusually complete information on their demographics.

Internet sleuthing by the Guardian revealed that Surgisphere had a scant online presence, with only a handful of staff listed on LinkedIn including a science fiction author and an adult model.

The firm was involved in yet another attention-grabbing study that found the anti-parasite drug ivermectin could be useful against COVID-19.

Though this paper had not been peer-reviewed or appeared in a journal, it caused a run on the drug in Latin America where it is widely available.

Chris Chambers, a professor of psychology at Cardiff University, added the affair "raises serious questions about the standard of editing at the Lancet and NEJM -- ostensibly two of the world's most prestigious medical journals."

https://www.france24.com/en/20200605-th ... uine-risks
#15097992
Hindsite wrote:an old malaria and rheumatoid arthritis drug now backed by many US conservatives against the SARS-CoV-2 virus.

A major study of thousands of patients led by University of Oxford shows the drug is ineffective.

"This is an incredibly important result, because worldwide we can stop using a drug that is useless.”


:)
#15097996
ingliz wrote:A major study of thousands of patients led by University of Oxford shows the drug is ineffective.

"This is an incredibly important result, because worldwide we can stop using a drug that is useless.”

It is not useless. It has been used for malaria, lupus, and arthritis for as long as 60 years with success. It has also been tried and appears to be successful, if used early enough, against Covid-19. That is why they have resumed test studies because the fake study that said it was dangerous was shown to be bogus.
#15098012
ingliz wrote:A major study of thousands of patients led by University of Oxford shows the drug is ineffective.

"This is an incredibly important result, because worldwide we can stop using a drug that is useless.”


:)


:knife:

Gellad said that he is curious to see the results of other ongoing studies, and that it is still an open question whether the medicine might work earlier in the disease. “We need real answers there as well,” he said.

Robert Califf, the former Food and Drug Administration commissioner and Alphabet employee, tweeted that the study “essentially rules out benefit of [hydroxychloroquine] in critically ill hospitalized patients.” He wrote that the results showed “no benefit; no major risk.”

https://www.statnews.com/2020/06/05/hyd ... e-of-drug/



And because the study hasn't been published or peer reviewed we're missing a lot of important details like how old and sick the subjects were. And HCQ wasn't used in combination with AZT or zinc which is what doctors say is what's getting the positive results.

We've seen so much HCQ junk science collapse by now that it's probably a good idea to wait to see the details before abandoning this treatment. Especially when so many doctors are reporting success with the HCQ+AZT+Zinc combination.
#15098014
Sivad wrote:And because the study hasn't been published or peer reviewed we're missing a lot of important details like how old and sick the subjects were. And HCQ wasn't used in combination with AZT or zinc which is what doctors say is what's getting the positive results.

We've seen so much HCQ junk science collapse by now that it's probably a good idea to wait to see the details before abandoning this treatment. Especially when so many doctors are reporting success with the HCQ+AZT+Zinc combination.

Yeah, I think you have the right attitude. However, I am 76 and would be willing to try it early if I got covid-19, since there is strong evidence for years that it is not harmful. Even President Trump took it for 14 days and he is still alive and kicking.
Praise the Lord.
#15098018
Hindsite wrote:it is not harmful.

SIDE EFFECTS

The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds.

Blood and lymphatic system disorders : Bone marrow failure, anemia, aplastic anemia, agranulocytosis, leukopenia, and thrombocytopenia. Hemolysis reported in individuals with glucose-6- phosphate dehydrogenase (G-6-PD) deficiency.

Cardiac disorders : Cardiomyopathy which may result in cardiac failure and in some cases a fatal outcome (see WARNINGS and OVERDOSAGE). PLAQUENIL prolongs the QT interval. Ventricular arrhythmias and torsade de pointes have been reported in patients taking PLAQUENIL (see OVERDOSAGE and DRUG INTERACTIONS).

Ear and labyrinth disorders : Vertigo, tinnitus, nystagmus, nerve deafness, deafness.

Eye disorders : Irreversible retinopathy with retinal pigmentation changes (bull's eye appearance), visual field defects (paracentral scotomas) and visual disturbances (visual acuity), maculopathies (macular degeneration), decreased dark adaptation, color vision abnormalities, corneal changes (edema and opacities) including corneal deposition of drug with or without accompanying symptoms (halo around lights, photophobia, blurred vision).

Gastrointestinal disorders : Nausea, vomiting, diarrhea, and abdominal pain.

General disorders and administration site conditions : Fatigue.

Hepatobiliary disorders : Liver function tests abnormal, hepatic failure acute.

Immune system disorders : Urticaria, angioedema, bronchospasm

Metabolism and nutrition disorders : Decreased appetite, hypoglycemia, porphyria, weight decreased.

Musculoskeletal and connective tissue disorders : Sensorimotor disorder, skeletal muscle myopathy or neuromyopathy leading to progressive weakness and atrophy of proximal muscle groups, depression of tendon reflexes and abnormal nerve conduction.

Nervous system disorders : Headache, dizziness, seizure, ataxia and extrapyramidal disorders such as dystonia, dyskinesia, and tremor have been reported with this class of drugs.

Psychiatric disorders : Affect/emotional lability, nervousness, irritability, nightmares, psychosis, suicidal behavior.

Skin and subcutaneous tissue disorders : Rash, pruritus, pigmentation disorders in skin and mucous membranes, hair color changes, alopecia. Dermatitis bullous eruptions including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), photosensitivity, dermatitis exfoliative, acute generalized exanthematous pustulosis (AGEP). AGEP has to be distinguished from psoriasis, although PLAQUENIL may precipitate attacks of psoriasis. It may be associated with pyrexia and hyperleukocytosis.


:)
#15098020
ingliz wrote:SIDE EFFECTS

The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds.

That is more bullshit. Practically all medications have side effects for high doses and over doses. That is why a person has to get a doctors prescription.
#15098022
ingliz wrote:SIDE EFFECTS

The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds.

Blood and lymphatic system disorders : Bone marrow failure, anemia, aplastic anemia, agranulocytosis, leukopenia, and thrombocytopenia. Hemolysis reported in individuals with glucose-6- phosphate dehydrogenase (G-6-PD) deficiency.

Cardiac disorders : Cardiomyopathy which may result in cardiac failure and in some cases a fatal outcome (see WARNINGS and OVERDOSAGE). PLAQUENIL prolongs the QT interval. Ventricular arrhythmias and torsade de pointes have been reported in patients taking PLAQUENIL (see OVERDOSAGE and DRUG INTERACTIONS).

Ear and labyrinth disorders : Vertigo, tinnitus, nystagmus, nerve deafness, deafness.

Eye disorders : Irreversible retinopathy with retinal pigmentation changes (bull's eye appearance), visual field defects (paracentral scotomas) and visual disturbances (visual acuity), maculopathies (macular degeneration), decreased dark adaptation, color vision abnormalities, corneal changes (edema and opacities) including corneal deposition of drug with or without accompanying symptoms (halo around lights, photophobia, blurred vision).

Gastrointestinal disorders : Nausea, vomiting, diarrhea, and abdominal pain.

General disorders and administration site conditions : Fatigue.

Hepatobiliary disorders : Liver function tests abnormal, hepatic failure acute.

Immune system disorders : Urticaria, angioedema, bronchospasm

Metabolism and nutrition disorders : Decreased appetite, hypoglycemia, porphyria, weight decreased.

Musculoskeletal and connective tissue disorders : Sensorimotor disorder, skeletal muscle myopathy or neuromyopathy leading to progressive weakness and atrophy of proximal muscle groups, depression of tendon reflexes and abnormal nerve conduction.

Nervous system disorders : Headache, dizziness, seizure, ataxia and extrapyramidal disorders such as dystonia, dyskinesia, and tremor have been reported with this class of drugs.

Psychiatric disorders : Affect/emotional lability, nervousness, irritability, nightmares, psychosis, suicidal behavior.

Skin and subcutaneous tissue disorders : Rash, pruritus, pigmentation disorders in skin and mucous membranes, hair color changes, alopecia. Dermatitis bullous eruptions including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), photosensitivity, dermatitis exfoliative, acute generalized exanthematous pustulosis (AGEP). AGEP has to be distinguished from psoriasis, although PLAQUENIL may precipitate attacks of psoriasis. It may be associated with pyrexia and hyperleukocytosis.


:)


Do you ever know what you're talking about? From the study you posted:

Hydroxycholoroquine: Chloroquine (CQ), an antimalarial drug discovered in 1934 and
introduced generally in 1947, is the drug to which humans have been most exposed, with
an annual global consumption of hundreds of metric tonnes for over 50 years. It is
inexpensive, simple to administer, and, at the appropriate doses, has an excellent safety
profile in all age groups and has been the prophylactic drug of choice in pregnancy
#15098024
Hindsite wrote:bullshit

Take the pill (with any luck it will prove fatal).

Have a nice day.

@Sivad

No drug is 100% safe and they should only be taken for good clinical reasons.

the study

I merely listed the adverse reactions as reported by the manufacturer. The manufacturer who urges patients to seek medical advice and report side effects if they experience them.


:)
Last edited by ingliz on 06 Jun 2020 18:15, edited 1 time in total.
#15099364
Prof. Raoult: when the Marx Brothers do science, the example of the RECOVERY study
https://m.youtube.com/watch?v=q8XQ4JAfkps

The Recovery trials preliminary results: quite a lot of methodology issues once again pointing at a loss of standards in scientific studies...
Issues with:
1. Criteria to define the disease
2. Ignoring the 3 very different stages in the disease development
3. Unreasonable dosage of hydroxychloroquine: 4 times higher than the usual protocols
4. No follow up in testing of patients for their viral load
5. Mortality rates so high that they do not match any other observations anywhere, even in pure ICU settings.
#15100702
rule of thumb: if rump says something is good, it is bad. if rump says something is bad, it is good. word on the street is that a side effect of hydrox etc. reduces penis size :eek: .


But …………. here is some great news from a reliable source:

Scientists at the University of Oxford said on Tuesday that they have identified what they called the first drug proven to reduce coronavirus-related deaths, after a 6,000-patient trial of the drug in Britain showed that a low-cost (the $1000 per pill boys won't like this) steroid could reduce deaths significantly for hospitalized patients.

The steroid, dexamethasone, reduced deaths by a third in patients receiving ventilation, and by a fifth in patients receiving only oxygen treatment, the scientists said. They found no benefit from the drug in patients who did not need respiratory support.
#15100730
This finding led the World Health Organization to temporarily suspend clinical trials into the medicines, though the paper soon triggered widespread concern among scientists over a lack of information about the countries and hospitals that contributed data.

But Surgisphere, a little-known healthcare analytics firm based in Chicago that provided the data, refused to cooperate.

"Due to this unfortunate development, the authors request that the paper be retracted," the three said.


The three researchers are from India and they know each other. One of them founded the healthcare analytics firm which provided the study with the faulty data. These Indian researchers' past studies are now being reviewed and one of the authors was fired by the University of Utah.

#15109900
Yale epidemiologist says hydroxychloroquine is 'the key to defeating COVID-19'
'Tens of thousands of patients with COVID-19 are dying unnecessarily' without the drug, he argues.

Harvey Risch, a professor of epidemiology at Yale as well as the director of that school's Molecular Cancer Epidemiology Laboratory, argues in a Newsweek op-ed this week that "the data fully support" the wide use of hydroxychloroquine as an effective treatment of COVID-19.

"When this inexpensive oral medication is given very early in the course of illness, before the virus has had time to multiply beyond control, it has shown to be highly effective," Risch argues in the column.

Risch, at Newsweek, argues that multiple studies over the past several months have demonstrated that the drug is a safe and efficacious treatment method for COVID-19.

Among the successful treatment experiments, he writes, are "an additional 400 high-risk patients treated by Dr. Vladimir Zelenko, with zero deaths; four studies totaling almost 500 high-risk patients treated in nursing homes and clinics across the U.S., with no deaths; a controlled trial of more than 700 high-risk patients in Brazil, with significantly reduced risk of hospitalization and two deaths among 334 patients treated with hydroxychloroquine; and another study of 398 matched patients in France, also with significantly reduced hospitalization risk."

Risch says the drug is most effective "when given very early in the course of illness, before the virus has had time to multiply beyond control."

Though according to Risch the benefits of the drug are clear, he nevertheless concedes that the subject "has become highly politicized."

"For many, it is viewed as a marker of political identity, on both sides of the political spectrum," he said. "Nobody needs me to remind them that this is not how medicine should proceed."

He also argues that "the drug has not been used properly in many studies," and that delays in administering the drug have reduced its effectiveness.

"In the future," Risch says in the column, "I believe this misbegotten episode regarding hydroxychloroquine will be studied by sociologists of medicine as a classic example of how extra-scientific factors overrode clear-cut medical evidence."

"But for now," he adds, "reality demands a clear, scientific eye on the evidence and where it points."

https://justthenews.com/politics-policy ... g-covid-19


The adults in the room are retard scientistics with their babbitt heads all the way up their babbitt asses.

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