No. That's false. You're spreading a lie based on an assumption about something you haven't a clue about. This has been demonstrated time and time again in your absolutely foolish postings. You'd ignore 1,000 other studies if they didn't say what you wanted them to say.Addressing Geert Vanden Bossche’s ClaimsNot only would people lose vaccine-mediated protection but also their precious, variant-nonspecific (!), innate immunity will be gone (this is because vaccinal antibodies outcompete natural antibodies for binding to Covid-19, even when their affinity for the viral variant is relatively low).
This is absolute, unvarnished nonsense. Bossche is referencing the production of natural IgM, which is generated by B1-B cells as a stopgap measure against infections until more potent responses can be initiated; these antibodies are polyreactive, nonspecific, and critically: constitutively produced. They are always present for as long as B1-B cells generating them live. IgM is pentameric and thus even though it has lower affinity than antibodies that have had the opportunity to evolve superior binding affinity, it can compensate with the fact that it has 10 binding sites instead of 2. However, IgG antibodies bear many of the same effector functions (actually, they tend to be better at many of them, as Table 10.27 shows) and they can diffuse into extravascular sites unlike IgM. Principally, antibodies against SARS-CoV-2 could be of value if they are neutralizing. Bossche presents no evidence to support that natural IgM is neutralizing (rather than just binding) SARS-CoV-2.
He then commits an immunological faux pas so egregious that it genuinely shocks me where he shows a dendritic cell (DC) activating an NK cell via antigen presentation on an MHC class I protein. It is basically at this point that I cannot presume that this letter is written in good faith given Dr. Bossche’s background. This is absolutely not how NK cells work. For one thing, the presence of MHC class I protein on a cell indicates to an NK cell that no viral infection is present and functions as an inhibitory signal (indeed, it is a common feature that viruses suppress expression of MHC class I proteins on cells they infect because this prevents them from being recognized by cytotoxic T cells that can kill the cell they are relying on to replicate). For another, NK cells do not examine the contents of the antigen in the MHC binding cleft. They do not have T cell receptors (with the exception of iNKT cells) and therefore have no ability to do this. There ARE reciprocal NK cell-DC interactions where each supports the other (e.g. DCs may produce cytokines promoting the activation of NK cells and NK cell cytokines can promote DC maturation, and NK cells have been known to kill immature dendritic cells in the body) but the mechanism proposed here is overtly at odds with decades of immunology research.
Frankly, to focus on NK cells for a vaccine against an infectious disease is extremely unusual (they can be very important in cancer immunotherapy though). The goal of vaccines broadly is to elicit long-lived immunological memory against a particular infectious agent. NK cells are part of the innate immune system, and while they do exhibit epigenetic modifications after infection in what has been termed trained immunity, this is not the principle by which most vaccines work. Vaccines have to achieve robust activation of dendritic cells because they are key antigen presenting cells and they need to trigger generation of memory helper T cells, ideally T follicular helper cells, memory B cells, long-lived plasma cells, and potentially cytotoxic T cells (depending on the agent)- they act virtually independently of NK cells (though NK cells may play a supportive role through ADCC on challenge with the antigen).https://www.deplatformdisease.com/blog/ ... hes-claims
There's more there, but I am sure you'll ignore it, as it debunks "hero's" BS.
@JB70 ,I know your anti-vax agenda of idiocy. If you spam all day long it still won't make what you say real or true.
“Let me never fall into the vulgar mistake of dreaming that I am persecuted whenever I am contradicted.” ― Ralph Waldo Emerson